Health Journey: Healthspan
Rapamycin—a compound first uncovered as an anti-fungal agent and later developed as an immunosuppressant—has recently emerged as a fascinating contender in the quest for longevity. Central to its potential anti-aging benefits is its impact on mTOR (mechanistic Target of Rapamycin), a critical pathway influencing cellular growth and metabolism.
Why mTOR Matters for Longevity
Rapamycin essentially mimics the effects of caloric restriction, one of the most robust and well-documented methods for extending the lifespan of various species. By inhibiting mTOR, it not only slows down processes linked to aging but also stimulates autophagy—a kind of cellular cleanup crew that removes damaged components, helping to keep cells youthful and efficient.
While mTOR and autophagy were the initial factors that piqued my interest, rapamycin is also thought to influence inflammation and stem cell function, which could further enhance its longevity benefits.
Dr. Peter Attia's Influence
My deep dive into rapamycin was sparked by Dr. Peter Attia, whose work I’ve followed closely through his videos (like this one, this one, or this one) and his book Outlive, which is fantastic. His thoughtful exploration of longevity strategies convinced me to give rapamycin a try, along with several other things, but this isn't about those.
Starting My Rapamycin Protocol
When I decided to explore rapamycin, I was pointed to Healthspan—a virtual provider specializing in longevity-focused products and services. Their process was refreshingly simple:
1. Answer a series of health and lifestyle questions.
2. Meet with a team member and a doctor to discuss your goals.
3. Begin a personalized protocol tailored to your needs.
Healthspan offers other products and services, but my focus remains solely on rapamycin for now.
My Experience So Far
My protocol involves taking rapamycin weekly (your dosing schedule may vary). I chose Sundays as my designated day because mTOR inhibition can interfere with muscle-building. By aligning my dose with my rest days, I avoid compromising the strength-training gains from my early Monday morning workouts.
Initially, I noticed a temporary "hollowed-out" feeling on the day I took it—a side effect likely linked to its immunosuppressive properties. Thankfully, this sensation is short-lived due to rapamycin’s brief half-life, and I’m back to normal the following day and ready for my early morning workout.
Rapamycin’s ability to enhance longevity is an exciting frontier, but there's still more research needed, so please do your own.
